Amyloid Precursor Protein Signalosome: directing Abeta production in Alzheimer's disease

阿尔茨海默病是最常见的痴呆症形式，也是发达国家的第四大杀手。淀粉样前体蛋白通过产生一种名为Abeta的有毒多肽，在疾病的发展中发挥核心作用。在这个项目中，我们将破译蛋白质外观的精细分子细节，以及已知的各种与蛋白质结合的分子如何影响Abeta的产生。这一知识有望带来治疗这种疾病的新疗法。

Alzheimer's disease is the most common form of dementia and is the fourth biggest killer in developed countries. Amyloid precursor protein plays a central role in the development of the disease, through the generation of a toxic peptide called Abeta. In this project we will decipher the fine molecular details of what the protein looks like and how various molecules known to bind to it affect Abeta production. This knowledge is expected to lead to novel therapies to treat the disease.