Real-time visualisation of dendritic cell responses during cutaneous Leishmania infection

利什曼病是世卫组织确定的需要进一步深入研究的六种主要热带病之一。这种疾病影响了全世界数百万人，需要开发改进的疫苗。一个先决条件是更好地了解抗寄生虫免疫的基本机制。该提案将采用一种新颖的方法，活体双光子显微镜，直接可视化皮肤中的利什曼原虫寄生虫和免疫细胞，以破译抗利什曼原虫免疫。

Leishmaniasis is one of the six major tropical diseases identified by the WHO for intense further study. The disease affects millions of people worldwide demanding the development of improved vaccines. A prerequisite is a better understanding of the basic mechanisms of anti-parasite immunity. This proposal will employ a novel approach, intravital two-photon microscopy, to directly visualise Leishmania parasites and immune cells in the skin in order to decipher anti-Leishmania immunity.