The actions of naltrexone in midbrain reward circuits

酒精使用障碍给个人饮酒者、他们的家人和社区带来了沉重的负担。阿片受体拮抗剂纳曲酮是治疗酒精使用障碍的为数不多的药物疗法之一，但其疗效与其发展有关，仅是有限的，而且仍然知之甚少。该项目使用最先进的基础科学方法来确定纳曲酮是如何实现其治疗效果的，并将确定改善这些效果的新方法。

Alcohol use disorders impose significant burden on individual drinkers, their families, and communities. The opioid receptor antagonist naltrexone is one of the few available pharmacotherapies for alcohol use disorders, but its efficacy was incidental to its development, is only modest, and remains poorly understood. This project uses state of the art basic science approaches to identify how naltrexone achieves its therapeutic effects and will identify new ways of improving these.