Analysis of the osteoclast methylome for characterisation of epigenetic mechanisms underlying metabolic bone disease

大量的基因变异已经被发现在骨质疏松症中起作用，然而对于其中的许多，它们影响疾病的机制仍有待确定。这项研究将通过研究破骨细胞(骨吸收细胞)基因表达的表观遗传控制来填补一个关键的知识空白。这项研究将产生一个独特的国际资源，为了解和治疗这种流行的和衰弱的骨骼疾病提供基础数据。

A large number of genetic variants have been identified that have a role in osteoporosis, however for many of these, the mechanism by which they influence the disease remains to be determined. This study will fill a critical knowledge gap by investigating the epigenetic control of gene expression in osteoclasts (bone resorbing cells). This research will generate a unique international resource that will provide foundation data to understand and treat this prevalent and debilitating bone disease.