Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity

蒽环类药物是化疗中最有效的药物之一，但会引起副作用，导致严重的心脏问题，可能是致命的。蒽环类药物治疗和它们在心脏中引起的问题之间的联系还没有完全确定。我们将研究导致这些副作用的机制，并确定蒽环类药物在心脏中的特定靶点。希望这将导致新药的设计，以抵消蒽环类药物治疗的副作用。

Anthracyclines are one of the most effective drugs used in chemotherapy, but cause side effects resulting in serious heart problems which can be fatal. The link between anthracycline therapy and the problems they cause in the heart is not fully defined. We will investigate mechanisms leading to these side effects and define specific targets of anthracyclines in the heart. It is hoped this will lead to the design of new drugs which counteract the side effects of anthracycline treatment.