Anti-Malarial Agents Targeting Apical Membrane Antigen 1

疟疾是一个主要的全球健康问题。AMA1蛋白在疟疾寄生虫入侵宿主细胞的过程中起着关键作用，抑制这种相互作用的药物可以防止宿主细胞入侵，因此代表了抗疟疾药物开发的线索。我们已经确定了一些针对AMA1关键位点的化学支架。在这个项目中，我们将优化这些引线，为这个位点生成有效的配体，并评估这些配体作为抗疟疾药物的功效。

Malaria is a major global health problem. The protein AMA1 plays a key role in the invasion of host cells by malaria parasites, and agents that inhibit this interaction prevent host cell invasion and thus represent leads for the development of anti-malarial drugs. We have identified a number of chemical scaffolds that target a key site on AMA1. In this project we will optimize these leads to generate potent ligands for this site and evaluate the efficacy of these ligands as anti-malarial agents.