The anti-thrombotic potential of immunoreceptors in platelet thrombus formation

血小板是血流中的小细胞，通过粘连在一起并形成止血栓，在防止组织损伤部位过度失血方面发挥重要作用。在患病的血管中，过多的血小板聚集可能会导致堵塞，并导致心脏病发作和中风等血栓性疾病，这是西方世界人类的两大杀手。在这个方案中，我们将试图了解血小板表面表达的免疫受体如何调节血小板胶原相互作用的功能，包括胶原GPVI受体、低亲和力Ig G受体、FcGammaRIIa和主要的血小板整合素-整合素αIIbbeta3。这项工作的目的将确定这些受体在血小板聚集中的作用，无论是在基于细胞的分析中，还是在小鼠血栓形成模型中。这项工作可能为血栓性疾病的治疗带来新的策略。

Platelets are small cells in the blood stream that play an important role in preventing excessive blood loss at sites of tissue injury by sticking together and forming a haemostatic plug. Excessive platelet clumping in diseased blood vessels can lead to blockages and cause thrombotic diseases such as heart attack and stroke, two of the biggest killers of humans in the western world. In this proposal, we will seek to understand how immunoreceptors expressed on the surface of platelets modulate the function of platelet collagen interactions involving collagen GPVI receptor, the low affinity IgG receptor, FcgammaRIIa and the major platelet integrin, integrin alphaIIbbeta3. The aims of this work will define the role of these receptors in platelet aggregation both in cell-based assays and in mouse models of thrombosis. This work could lead to new strategies for therapeutic management of thrombotic disorders.