Antibiotic Conjugates: Joining Together to Fight Antimicrobial Resistance

由于标准的抗生素疗法已经过时，迫切需要新的策略来治疗多药耐药细菌感染的增加。该项目将基于在现有抗生素支架上附加额外功能的核心概念，开发多种创新方法来克服抗生素耐药性。将合成新的缀合物，测试其抗菌活性，然后通过经过验证的抗菌开发管道进行优化。

New strategies are urgently needed to treat the rise of infections from multidrug-resistant bacteria, with standard antibiotic therapies becoming obsolete. This project will develop multiple innovative approaches to overcome antibiotic resistance, based on a core concept of appending additional functionality to existing antibiotic scaffolds. New conjugates will be synthesized, tested for antimicrobial activity, then optimized via a validated antimicrobial development pipeline.