The Arthroplasty Surgical Antibiotic Prophylaxis (ASAP) Study

全关节置换手术的需求将在未来十年翻一番。手术伤口感染是这种手术的一个毁灭性的并发症。所有感染的一半是由于耐甲氧西林葡萄球菌（如MRSA）和肠球菌。这项多中心随机对照试验旨在研究手术时添加万古霉素是否能降低手术伤口感染的发生率;是否安全且具有成本效益。

The demand for total joint replacement surgery will double over the next decade. Infection involving the surgical wound is a devastating complication of this surgery. Half of all infections are due to methicillin resistant Staphylococcus (such as MRSA) and Enterococcus. This multicentre randomised controlled trial aims to investigate whether the addition of vancomycin at the time of surgery reduces the incidence of surgical wound infections; is safe and is cost-effective.