The contribution of gp130-Stat3 during Wnt-beta-catenin induced intestinal cancer

越来越多的证据表明，癌症的产生和发展不是由单个基因或信号通路的失调引起的，而是由多个事件引起的。我们将研究gp130-Stat和Wnt两条通路之间的协同作用。这些信号通路在许多类型的癌症中经常被解除调控，然而它们之间的相互作用仍然知之甚少。我们将探索它们在肠癌期间的相互作用机制，以开发新的治疗靶点。

There is growing evidence that cancer is initiated and develops not by the deregulation of a single gene or signaling pathway, but by multiple events. We will study the co-operation between two pathways - gp130-Stat and Wnt. These signaling pathways are frequently deregulated in many types of cancer, however their interaction remains poorly understood. We shall explore their mechanism of interaction during intestinal cancer in order to develop a novel therapeutic target for this disease.