The Effect of Aging on Cardiovascular Disease Prediction

心血管疾病是老年人死亡和残疾的主要原因。我们的目标是调查：（i）传统CVD风险因素预测老年人主要不良心血管事件（MACE）的能力及其与虚弱的相互作用（ii）CT冠状动脉造影片上斑块负荷预测老年人群MACE的能力及其与传统风险评分相比的增量预测值（iii）血小板活化途径是否随年龄增加而不同

Cardiovascular disease is a leading cause of death and disability in the elderly. We aim to investigate: (i) the ability of traditional CVD risk factors to predict major adverse cardiovascular events (MACE) in the elderly and their interaction with frailty (ii) the ability of plaque burden on CT coronary angiogram to predict MACE in older populations and its incremental predictive value compared to traditional risk scoring (iii) whether platelet activation pathways differ with increasing age