The effects of tonic muscle pain on the sympathetic and somatic motor systems in human subjects

这项建议的主要目的是揭示人类伤害性反射的影响，从而确定其功能和临床意义。通过对控制长期（约1小时）实验性疼痛的健康志愿者的血管和肌肉的神经进行侵入性记录，这项工作将增加我们对疼痛诱导的适应性变化的理解，并改善治疗方法，以防止疼痛成为慢性。

The main objective of this proposal is to reveal the effects of nociceptive reflexes in humans, and thus identify their functional and clinical implications. By performing invasive recordings from the nerves that control blood vessels and muscles in healthy volunteers subjected to long-lasting (~1 hour) experimental pain, this work will increase our understanding of the adaptive changes that pain induces and improve treatments to prevent pain from becoming chronic.