The Genetic Epidemiology of Childhood Leukaemias

白血病是儿童癌症中最常见的一种，是澳大利亚整体癌症负担的重要组成部分。我们的目标是提高我们对这种疾病的遗传和家族因素的理解。通过建立维多利亚儿科家庭癌症研究，我们获得了母亲年龄、白血病发病和家庭总癌症风险之间的关系的证据。我们的目标是确定这一发现是否基于基因，这意味着遗传成分比之前认识到的更大。

Leukaemia, the most common form of childhood cancer, constitutes an important component of Australia's overall cancer burden. We aim to improve our understanding of the genetic and familial contributions to this disease. By establishing the Victorian Paediatric Family Cancer Study, we have evidence of a relationship between maternal age, onset of leukaema and overall risk of cancer in the family. We aim to determine if this finding is genetically based, implying a larger inherited component than previously recognized.