The genetics and mechanisms of resistance to the zoonotic highly pathogenic influenza virus in avian species

高致病性禽流感(HPAI)构成严重的大流行风险。该项目将调查禽类对HPAI的遗传基础和潜在的抗药性机制。它将探索免疫基因在六种鸟类对HPAI的抵抗力中所起的作用，这些鸟类对HPAI的敏感度不同。将对抗性基因进行功能测试，以确定这些基因如何提供对HPAI的抗性。这项研究将有助于制定减轻疾病风险的战略。

Highly pathogenic avian influenza (HPAI) poses a serious pandemic risk. This project will investigate the genetic basis and mechanisms underlying resistance to HPAI in birds. It will explore the role of immune genes in resistance to HPAI in six bird species which vary in their susceptibility to HPAI. Functional tests of resistance genes will be performed to determine how these genes can provide resistance to HPAI. This study will assist in the development of strategies to mitigate disease risks.