The inflammasome and autoinflammatory disease

免疫系统有两条臂膀，一条是学习和适应，这可能导致自身免疫性疾病，另一条是直接和先天的，可能导致自身炎症性疾病。这一建议继续我们在罕见的遗传性自身炎症疾病的表征方面的工作，并将这些研究推断为更常见的慢性炎症疾病。这有助于改善当前的诊断和治疗，并阐明未来可能在临床上靶向的药物靶点。

There are two arms to the immune system, one that learns and adapts, which can cause autoimmune disease, and another that is immediate and innate, and can cause autoinflammatory disease. This proposal continues our work in the characterization of rare genetic autoinflammatory disesaes and extrapolates these studies to more common chronic inflammatory diseases. This stands to improve current diagnosis and treatment, and elucidate future drug targets that could be targeted clinically.