The interaction of Ac45 with V-ATPase and its function in osteoclastic bone resorption

骨质疏松症是一种以低骨量和骨组织结构退化为特征的疾病，导致骨脆性和骨折易感性增加。值得关注的是，老年人的骨质疏松性骨折与死亡率增加有关。此外，与过度骨吸收相关的疾病给卫生保健系统带来了巨大的经济负担。我们将研究质子泵在骨吸收中的作用，作为治疗骨质疏松症的潜在靶点。

Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and increased susceptibility to fractures. Of concern is osteoporotic fractures in the elderly are linked with increased mortality rates. Also, diseases associated with excess bone resorption place significant financial burden on the health care systems. We will examine the role of proton pump in bone resorption as a potential target for the treatment of osteoporosis.