The Iron Clock: Epigenetic regulation of circadian iron homeostasis

血液中的铁水平会随着一天的变化而波动，但造成这种波动的原因一直没有确定。正如胰岛素对葡萄糖动态平衡至关重要，海普西丁从根本上调节铁代谢。该项目将确定铁水平的主要调节剂海普西丁在24小时周期内变化的机制。它将使用一系列尖端技术来精确定位该系统的关键调控因素，并提供科学和临床可翻译的知识。

Levels of iron in the blood fluctuate over the day, but the reasons for this have never been defined. Just as insulin is critical to glucose homeostasis, hepcidin fundamentally regulates iron metabolism. This project will define the mechanisms by which the master regulator of iron levels, hepcidin, varies across a 24 hour cycle. It will use a series of cutting edge techniques to pinpoint the key regulators of this system and provide both scientific and clinically translatable knowledge.