Cellular Organisation of Protective Immune Responses

我们的免疫系统由一组白血球组成，它们协同对抗入侵的病原体。研究表明，细胞受体CXCR3控制免疫细胞相互作用，在初始细胞激活和病毒感染过程中决定免疫控制和保护。该项目将采用多学科的方法，结合病毒免疫学、独特的小鼠模型、先进的成像和生物信息学分析来剖析支撑免疫保护的细胞对话。揭示免疫反应期间细胞相互作用的机制将对开发靶向疫苗和治疗方法（特别是针对慢性感染和癌症）产生重大影响，这些都是主要的健康负担。

Our immune system consists of a task force of white blood cells that coordinate to defeat invading pathogens. Research has revealed a cell receptor, CXCR3, controls immune cell interactions, which determine immune control and protection during initial cell activation and viral infection. This project will use a multi-disciplinary approach combining viral immunology, unique mouse models, advanced imaging, and bioinformatic analyses to dissect the cellular conversations that underpin immune protection. Revealing the mechanisms of cellular interactions during an immune response will have a major impact on development of targeted vaccines, and therapeutics (particularly for chronic infections and cancer), which are major health burdens.