Aromatase regulation by p53 and HIF-1alpha in obesity and post-menopausal breast cancer.

目前使用雌激素生成抑制剂治疗乳腺癌的激素疗法会导致严重的副作用，包括骨质丢失、关节疼痛和可能的认知问题。我们目前的工作旨在了解雌激素的产生是如何调节的，目的是开发针对乳房的雌激素产生的抑制剂来避免这些问题。此外，这项工作旨在设计治疗干预措施，以打破肥胖和乳腺癌之间的联系。

Current hormone therapy for breast cancer using inhibitors of oestrogen production results in serious side-effects including bone loss, joint pain and possibly cognitive issues. Our current work is aimed at understanding how oestrogen production is regulated with the goal of developing breast-specific inhibitors of oestrogen production to obviate these problems. In addition, this work is aimed at devising therapeutic intervention to break the linkage between obesity and breast cancer.