Two recently identified calcium transporters in lactation and during mammary epithelial cell apoptosis.

钙进入牛奶的运输是人类健康的一个关键事件。除了对新生儿营养的重要性外，乳腺细胞调节钙的方式也对乳腺癌，以及对免疫和生物制药活性重要的蛋白质的修饰有影响。这项拨款将确定两种特定的钙转运蛋白如何调节乳房中的钙水平，以及它们在正常功能和疾病中重要的细胞过程中的各自作用。

The transport of calcium into milk is a key event in human health. In addition to its importance in neonatal nutrition, the way breast cells regulate calcium also has implications in breast cancer, as well as the modification of proteins important in immunity, and the activity of biopharmaceuticals. This grant will determine how two specific calcium transporters regulate calcium levels in the breast and their respective roles in cellular processes important in normal function and in disease.