Assessment of oxidant stress and mitochondrial dysfunction in young adults with iron loading diseases

铁代谢障碍在澳大利亚特别普遍，过量铁的后果可能很严重。肝脏疾病经常与铁负荷有关。最常见的铁负荷形式可以很容易地治疗，但尚不清楚组织损伤的第一个迹象是什么时候出现，因此治疗应该在什么阶段开始。该项目将详细研究患有铁负荷疾病的年轻受试者体内铁水平与组织损伤迹象之间的关系。

Disorders of iron metabolism are particularly prevalent in Australia and the consequences of excess iron can be severe. Liver disease is frequently associated with iron loading. The commonest form of iron loading can be treated readily, but it is unclear when the first signs of tissue damage occur and thus at what stage treatment should commence. This project will examine in detail the relationship between body iron levels and signs of tissue damage in young subjects with iron loading disease.