Assessment of rectal and urinary toxicity from the RADAR prostate radiotherapy trial – dosimetric constraints for novel symptom clustering, derivation of radiobiological parameters and assessment of patient localisation effects

通过增加放射剂量来提高前列腺放射治疗的治愈率受到直肠和膀胱副作用的限制，这些副作用会大大降低患者的生活质量。这项研究将利用在澳大利亚一项大型试验中收集的详细数据，提取有关剂量传递模式如何影响膀胱和直肠副作用的信息，包括直肠毒性的新定义。其结果将是未来的治疗更有效。

Increasing prostate radiotherapy cure rates by increasing radiation dose is limited by side-effects in the rectum and bladder which can greatly decrease patient quality of life. This study will utilise detailed data, collected during a large Australasian trial, to extract information on how patterns of dose delivery influence side-effects in the bladder and rectum, including a novel definition of rectal toxicity. The result will be more effective future treatment.