Biased allosteric modulators of metabotropic glutamate receptors: novel therapeutic targets for CNS disorders

代谢型谷氨酸受体5(MGlu5)是抑郁症和精神分裂症的主要治疗靶点。拟议的研究将提高我们对类药物化学物质如何与mGlu5相互作用的理解，从而改变这些受体的活性，进而改变脑细胞的活性，从而产生治疗效果。该项目中进行的研究将使我们能够更聪明地开发既有效又副作用最小的mGlu5新药。

Metabotropic glutamate receptor 5 (mGlu5) is a major therapeutic target for depression and schizophrenia. The proposed studies will improve our understanding of how drug-like chemicals interact with mGlu5 and therefore change the activity of these receptors and in turn the activity of brain cells leading to therapeutic effectiveness. The research undertaken in this program will allow us to be smarter in developing new mGlu5 drugs that are both effective and have minimal side effects.