Biomarkers in Barrett's Oesophagus and Oesophageal Adenocarcinoma

巴雷特食管（BO）是一种由于长期胃酸反流，食管下部的正常内层被肠样组织取代的疾病。BO可发展为食道腺癌（OAC），这是一种侵袭性癌症，5年生存率约为15%。该项目旨在检测BO和OAC中发生的遗传和分子变化，这些变化可能有助于预测受该疾病实体影响的患者的进展风险和生存。

Barrett’s oesophagus (BO) is a condition in which the normal lining of the lower oesophagus is replaced with intestine-like tissue as a response to long-standing acid reflux. BO can progress to oesophageal adenocarcinoma (OAC), an aggressive cancer with poor 5-year survival rates of ~15%. This project aims at detecting genetic and molecular changes that occur in both BO and OAC and which may help predict the risk of progression as well as survival for patients affected by this disease entity.