Bisphosphonate use, oral flora, saliva, gingival crevicular fluid and bone markers in patients with jaw osteonecrosis

双膦酸盐用于骨质疏松症等骨质容易断裂的患者。最近的研究表明，这些药物和颌骨断裂之间可能存在联系，称为颌骨坏死-一种目前没有有效治疗的破坏性疾病。目前还不清楚为什么这种情况只影响颌骨。这项研究旨在调查口腔中的细菌、牙龈疾病和唾液是否与颌骨骨坏死有关，这有助于改善治疗。

Bisphosphonates are used in patients with bones that break easily due to conditions such as osteoporosis. Recent research suggests a possible association between these drugs and jaw bone breakdown called jaw osteonecrosis - a devastating condition with no current effective treatment. It is unclear why this condition affects only jaw bones. This study seeks to investigate if bacteria in the mouth, gum disease and saliva are involved in jaw osteonecrosis, which can then help to improve management.