Bitopic ligands as a novel approach to G-protein-coupled receptor selectivity

这个项目将专注于两种重要的大脑蛋白质，它们与精神分裂症的各种症状有关。其目的是利用我们已经发现的一种新的药物作用范例，利用新的化合物可以同时靶向这些大脑蛋白质上的多个位置，以努力发现新的机制，可以促进更有选择性的信号传递，并最终可以用于设计更安全和更有效的药物。

This project will focus on two important types of brain proteins that have been implicated in various symptoms associated with schizophrenia. The aim is to exploit a new paradigm of drug action that we have discovered, whereby novel compounds can be utilized to simultaneously target multiples sites on these brain proteins, in an effort to discover new mechanisms that can promote more selective signalling and, ultimately, can be used to design safer and more effective medicines.