Building mitochondrial Complex I, the first assembly of the cells powerplant.

复合体I是线粒体呼吸链的第一个复合体，参与产生细胞的大部分能量。线粒体疾病约有1- 5000例活产，其中复合物I的缺陷最为普遍，往往导致死亡。复合物I缺陷也与帕金森病等常见疾病有关。这项研究将提供重要的新信息，了解复合体I是如何构建的，以及什么地方出了问题导致疾病。

Complex I is the first complex of the mitochondrial respiratory chain that is involved in producing most of the cell's energy. Mitochondria diseases occur ~1-5,000 live births with defects in Complex I being the most prevalent, often leading to death. Complex I defects have also been implicated in common disease including Parkinson s disease. This study will provide important new information into how Complex I is built and what goes wrong to cause disease.