Accessing the therapeutic potential of carbon monoxide

尽管一氧化碳被认为是“沉默的杀手”，但现在已经证实，这种分子对许多疾病和病理都有有益的影响，包括炎症、器官移植排斥反应、细菌感染、急性肝功能衰竭以及作为癌症治疗的辅助手段。该项目计划探索含Re物种的光化学，以发现更有效的一氧化碳递送剂。通过将合成化学、光化学和细胞生物学结合起来，预计这一多学科研究方案将通过为定向和受控输送一氧化碳制备更安全的制剂来推动一氧化碳疗法领域的发展。

Despite carbon monoxide being regarded as the ”silent killer”, it is now established that this molecule has beneficial effects for a number of conditions and pathologies, including inflammation, organ transplant rejection, bacterial infection, acute liver failure and as an aid in cancer therapies. This project proposes to explore the photochemistry of rhenium-containing species to discover more efficient carbon monoxide delivery agents. By combining synthetic chemistry, photochemistry and cellular biology it is anticipated that this multidisciplinary research programme will advance the area of carbon monoxide therapies by preparing safer agents for the targeted and controlled delivery of carbon monoxide.