Characterising the role of streptokinase polymorphism in invasive pathogenesis of Streptococcus pyogenes.

侵袭性细菌病原体，如化脓性链球菌，可以劫持宿主蛋白质并利用它们促进疾病进程。化脓性链球菌分泌链激酶来激活宿主蛋白酶（纤溶酶原），该酶被细菌用来侵入宿主组织。该项目将描述参与链激酶介导的纤溶酶原激活的分子机制，这将有助于产生治疗侵袭性疾病的新疗法。

Invasive bacterial pathogens such as Streptococcus pyogenes, can hijack host proteins and use them to facilitate the disease process. S. pyogenes secrete streptokinase to activate a host protease (plasminogen) which is used by the bacterium to invade through host tissue. This project will characterise the molecular mechanisms involved in streptokinase mediated activation of plasminogen which will assist the generation of novel therapeutics to treat invasive diseases.