Chemokines in osteoclast differentiation

趋化因子是一种小分子，当炎症发生时，由许多类型的细胞，特别是单核细胞释放。慢性炎症性疾病与严重的骨质侵蚀和骨质质量丧失有关。令人惊讶的是，趋化因子控制着破骨细胞的发育和巨噬细胞的激活；即使破骨细胞已经形成，阻止趋化因子信号传递也会阻止骨吸收。趋化因子是控制破骨细胞形成的新靶点。

Chemokines are small molecules that are released by a number of cell types, particularly monocytes, when inflammation occurs. Chronic inflammatory disease is associated with severe bone erosion and loss of bone quality. Surprisingly, chemokines control osteoclast development as well as macrophage activation; even if the osteoclast has formed, blocking chemokine signalling prevents bone resorption. Chemokines are a new and exciting target to control osteoclast formation.