A Phase 1b trial of specific immunotherapy for recurrent respiratory papillomatosis

该项目将确定免疫接种是否可用于有效治疗现有感染。到目前为止，免疫只用于预防感染，但在许多慢性感染中，干预可能有助于身体的防御更好地工作并清除慢性感染。在这项研究中，我们将研究这种方法是否可以应用于与癌症相关的病毒感染（乳头瘤病毒）。我们将测试针对慢性和危及生命的疾病的免疫接种，这种疾病会在呼吸道中生长疣，因为目前还没有令人满意的治疗方法。如果该项目取得成功，我们还可以了解哪些血液检查可能预测免疫治疗感染的结果。

This project will determine whether immunisation can be used to effectively treat an existing infection. To date, immunisation has only been used to prevent infection, but there are many chronic infections where intervention might help the body's defences to to a better job and clear the chronic infection. In this study, we will work out whether this approach can be applied to a virus infection ( papillomavirus) which is associated with cancer. We will test immunisation against a chronic and lifethreatening disorder in which warts grow in the respirarory tract, as there is currently no satisfactory treatment for this. If the project is successful we may also learn which blood tests are likely to predict the outcome of immunisation to treat infection.