The regulation of monocyte derived dendritic cells (moDCs) during allograft rejection

胰岛移植可以治愈1型糖尿病，但免疫抑制移植排斥反应所需的药物有副作用。因此，了解免疫排斥是如何发生的，以便我们能够以更谨慎的选择性方式抑制是我们的目标。在移植物排斥反应中表现突出的一类细胞是单核细胞来源的树突状细胞。我们认为这种细胞在排异过程中对协调免疫反应至关重要。因此，我们希望确定如何控制这些细胞。

Islet transplantation can cure type 1 diabetes, but the required drugs for immunosuppressing graft rejection have side effects. Therefore understanding how immune rejection occurs so that we can suppress in a more discreet selective way is our goal. A type of cell that is prominent during graft rejection is the monocyte derived dendritic cell. We propose that this cell is critical for orchestrating immune responses during rejection. Therefore we wish to determine how such cells are controlled.