Regulatory networks defining stem cell populations in the adult male germline

干细胞对于包括睾丸在内的许多成人组织的维持和修复是必不可少的。在一个给定的组织中，不同的干细胞群在组织维持和再生中发挥着不同的作用。我们已经在睾丸内发现了一组干细胞，这些干细胞具有一组在胚胎发育过程中至关重要的独特基因。我们的研究将评估这种新细胞群在男性生育和睾丸修复中的作用，并确定其功能所需的基因。

Stem cells are essential for maintenance and repair of many adult tissues including testis. Within a given tissue, different populations of stem cells can play contrasting roles in tissue maintenance and regeneration. We have identified a group of stem cells within the testis marked by a unique set of genes critical during embryo development. Our studies will assess the role of this new cell population in male fertility and testis repair and define genes required for its function.