Relationships between diet and gastric motor function in functional dyspepsia

功能性消化不良（FD）是一种以腹部症状为特征的疾病，其原因无法通过常规诊断测试识别。症状（如饱胀，腹胀）往往是由饮食引起的。在西方国家，20 - 40%的成年人口受到FD的影响，因此，这种情况对卫生保健系统来说是相当大的经济负担。FD对生活质量有不利影响。在许多FD患者中，胃收缩和胃的“敏感性”是异常的。通常，FD患者避免食用脂肪食物，因为他们认为这些食物会导致或加重症状。然而，关于饮食习惯在引起症状中的潜在作用、饮食与胃功能紊乱之间的关系以及饮食变化对症状的影响的信息很少。我们以前的研究表明营养素，特别是脂肪，在FD中起着重要作用。我们将讨论这一假设，即饮食因素，特别是脂肪摄入，对FD的病理生理和治疗有实质性的影响。我们的研究将涉及生理（胃排空，食欲和食物摄入）和流行病学（饮食习惯，消化不良症状和生活质量相关方面）的测量。FD患者将接受不同营养成分的标准化测试餐，我们将研究对他们的胃和症状的影响。我们还将测试一些药物，以试图减轻进食期间和进食后的症状，特别是在进食脂肪食物后。其他研究将评估FD患者的饮食习惯与症状发生的关系，并调查饮食干预（减少饮食中的脂肪含量，排除有害食物）对这些患者有益的可能性。拟议的研究将提供迄今为止FD患者症状与饮食习惯和胃功能之间关系的最全面的研究。

Functional dyspepsia (FD) is a condition characterised by abdominal symptoms without a cause that is identifiable by conventional diagnostic tests. Symptoms (eg fullness, bloating) are frequently induced by eating. 20 - 40 % of the adult population in Western countries are affected by FD, and the condition, therefore, represents a considerable financial burden to the health care system. FD affects quality of life adversely. In many people with FD, stomach contractions and the 'sensitivity' of the stomach are abnormal. Often, people with FD avoid fatty foods in the belief that these cause or exacerbate symptoms. There is, however, little information about the potential role of dietary habits in causing symptoms, the relationship between eating and disturbances in stomach function, and the impact of dietary changes on symptoms. Our previous studies suggest an important role for nutrients, particularly fat, in FD. We will address the hypothesis that dietary factors, particularly fat intake, have substantial implications for the pathophysiology and treatment of FD. Our studies will involve physiological (stomach emptying, appetite and food intake) and epidemiological (dietary habits, dyspeptic symptoms and quality of life-related aspects) measurements. The subjects-patients with FD will receive standardised test meals of varying nutrient composition, and we will study the effects on their stomach and on symptoms. We will also test some medications in an attempt to alleviate symptoms during and after food ingestion, particularly after fatty foods. Other studies will assess the dietary habits of patients with FD in relation to symptom occurrence and investigate the possibility that dietary intervention (reduction of fat content in the diet, exclusion of offending foods) will benefit these patients. The proposed studies will provide the most comprehensive studies to date of the relationship between symptoms in patients with FD with dietary habits and stomach function.