Research Fellowship

刘易斯教授是一位分子药理学家，致力于发现新的毒肽和雪卡毒素，并利用先进的生化和光谱方法确定它们如何与目标膜蛋白相互作用。然后对感兴趣的多肽进行修饰，以提高效力和选择性。那些具有适当特性的药物获得了专利，并使用成功应用于Xen2174的方法进行了临床应用开发。Xen2174是我与人共同发现的一种椰子肽类似物，目前正处于治疗剧烈疼痛的第二阶段临床试验中。

Professor Lewis is a molecular pharmacologist interested in discovering new venom peptides and ciguatoxins and determining how they interact with the membrane proteins they target using advanced biochemical and spectroscopic methods. Peptides of interest are then modified to improve potency and selectivity. Those with appropriate properties are patented and developed for clinical applications using approaches successfully applied to Xen2174, a conopeptide analogue I co-discovered that is now in Phase II clinical trials for severe pain.