Reversing age-related impairment of myelin repair - a novel therapy for MS

多发性硬化症(MS)是一种大脑和脊髓疾病，由髓鞘丢失引起，髓鞘通常绝缘神经细胞的轴突(电缆)。当髓鞘丢失时，电信号不能正常地沿着轴突传递。再生髓鞘是恢复正常神经功能的关键，但髓鞘修复会随着年龄的增长而恶化。我们将确定是否可以通过恢复髓鞘修复过程来逆转与年龄相关的髓鞘修复下降。

Multiple sclerosis (MS) is a disease of the brain and spinal cord caused by the loss of myelin which normally insulates the axons (cables) of nerve cells. When myelin is lost, electrical signals cannot pass along axons normally. Regenerating this myelin is key to restoring normal nerve function but myelin repair deteriorates with age. We will determine whether age-associated decline in myelin repair can be reversed by rejuvenating the myelin repair process.