Roadblocks to DNA replication and implications for antimicrobial resistance

抗微生物药物在其特异性靶向微生物感染的能力方面彻底改变了现代医学。然而，这些药物的过度使用导致越来越多的感染性微生物对它们产生耐药性。该计划旨在使用分子成像技术来可视化微生物如何对抗菌剂做出反应以及它们如何进化成为耐药性。该计划的成果将有助于确定药物靶点和开发诊断方法。

Antimicrobial drugs have revolutionised modern medicine in their ability to specifically target microbial infections. However, overuse of these drugs is resulting in more and more infectious microbes becoming resistant to them. This program aims to use molecular imaging techniques to visualise how microbes respond to antimicrobials and how they evolve to become resistant. The outcomes of this program will enable the identification of drug targets and the development of diagnostics.