The role of airway neutrophilia in the structural and functional characteristics of severe asthma and its effect on steroid-resistance

虽然许多哮喘病例是轻微的，但严重病例需要广泛的卫生保健资源，而且对常规治疗几乎没有反应。该项目将调查从呼吸道释放的特定化合物是否能够导致类似于严重哮喘的肺损伤和呼吸道异常。我们将调查这些变化是否对常规治疗有反应，并调查一种可能的治疗方法，以恢复对严重哮喘的这种反应。

While many cases of asthma are mild, severe cases require extensive health care resources and are virtually unresponsive to conventional treatment. This project will investigate whether specific compounds released from the airway are able to cause lung damage and airway abnormalities similar to that in severe asthma. We will investigate whether these changes are responsive to conventional therapy and investigate a potential treatment for regaining this responsiveness in severe asthma.