The role of co-signalling receptors in cytotoxic lymphocyte activity during infection and cancer

细胞毒性淋巴细胞（CLs）是检测并杀死癌细胞的免疫细胞。CLs通过专门的受体识别癌细胞上的“压力”蛋白，这为它们提供了杀死的信号。然而，一些癌细胞，如白血病细胞，可以干扰这种识别，以避免被免疫细胞杀死。本项目将利用小鼠模型和急性髓系白血病患者细胞，研究CLs识别和杀伤癌细胞的机制。

Cytotoxic lymphocytes (CLs) are immune cells that detect and kill cancer cells. CLs recognise ‘stress’ proteins on cancer cells through specialised receptors, and this provides the signal for them to kill. However, some cancer cells, such as leukemic cells, can interfere with this recognition to avoid killing by immune cells. This project will investigate the mechanism of recognition and killing of cancer cells by CLs, using both mouse models and cells from patients with acute myeloid leukemia.