Role for Dipeptidyl Peptidase-IV in the Innate Immune Response

先天免疫系统是bodyÍs抵御入侵生物感染的第一道防线。不适当的先天免疫反应可导致几种炎症性疾病的发展，如炎症性肠病。在IBD儿童中发现了先天免疫反应异常。该项目将确定一种称为DPIV的独特酶在先天免疫反应发展中的作用及其作为IBD治疗靶点的潜力。

The innate immune system is the bodyÍs first line of defence in fighting off infections by invading organisms. An inappropriate innate immune response can lead to the development of several inflammatory conditions such as inflammatory bowel disease. A malfunctioning innate immune response has been identified in children with IBD. This project will determine the role of a unique enzyme called DPIV in the development of innate immune responses and its potential as a therapeutic target for IBD.