Role of neuroinflammation and neurotransmitter systems in the improved cognition induced by estrogen receptor modulation

认知问题阻碍了精神分裂症患者的学习、工作和形成社会关系。目前尚无治疗认知问题的临床方法。我们发现雌激素受体调节剂雷洛昔芬可以改善精神分裂症患者的认知能力。确定有助于认知改善的分子机制将为开发更有效的治疗方法来增强认知和防止认知衰退提供分子靶点。

Cognitive problems prevent people with schizophrenia from studying, working and forming social connections. There are no clinical treatments for cognitive problems. We have found that the estrogen receptor modulator, raloxifene, improves cognition in people with schizophrenia. Determining the molecular mechanisms that contribute to this improvement in cognition will provide molecular targets for the development of more effective therapeutics to enhance cognition and prevent cognitive decline.