The role of paramyxovirus P protein subcellular trafficking in virus pathogenicity and antagonism of host interferon responses

新出现的人畜共患病病毒在全球范围内构成了重大的健康威胁，最近爆发的尼帕病毒和亨德拉病毒通过种间入侵感染人类突出了这一点。种间感染的一个主要障碍是先天免疫反应，病毒必须在成功感染之前进化以对抗先天免疫反应。我们的目标是详细研究这些病毒的免疫逃避机制，最终目标是发现治疗病毒感染的新靶点。

Emerging zoonotic viruses pose a major health threat worldwide, highlighted by recent outbreaks of viruses such as Nipah and Hendra via interspecies invasion to infect humans. A major barrier to interspecies infection is the innate immune response, which viruses must evolve to combat before successful infection can occur. We aim to examine in detail the mechanisms underlying immune evasion of such viruses, with the ultimate goal of discovering novel targets for therapeutics to viral infection.