Role of PTEN catalytic function in suppression of cancer and metastasis

PTEN突变经常在各种类型的癌症中描述。该提案概述了不同的实验策略，以探讨不同的PTEN功能的调制如何影响信号通路，并负责致癌的结果。我们将使用动物模型和培养的细胞系来识别新的特征/生物标志物，以在遗传和分子基础上对患者进行分层，并促进针对癌症根除的定制组合疗法的设计。

PTEN mutations are frequently described in various types of cancer. This proposal outlines different experimental strategies to probe how modulation of distinct PTEN functions can affect signalling pathways and be responsible for oncogenic outcomes. We will use animal models and cell lines in culture to identify new signatures/biomarkers to stratifying patients on genetic and molecular bases, and to facilitate the design of tailored combinational therapies directed toward cancer eradication.