The role of the secreted SVS7 protein in bone Homeostasis
The role of the secreted SVS7 protein in bone Homeostasis
批准号:
nhmrc : 572671
负责人:
Prof Jiake Xu
金额:
$40.35万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
骨质疏松症是一种以骨量减少和骨组织结构恶化为特征的疾病,导致骨骼脆性和由于不断重新吸收和重塑骨骼的细胞之间的不平衡而导致的骨折易感性增加。到2040年,随着我们的人口老龄化和因髋部骨折致残的个人的社会成本可能会增加两倍。这项拟议的项目研究了一种控制骨量的新因素。它的潜力是用于治疗。
英文摘要
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility and an increased susceptibility to fractures caused by imbalance between cells that are constantly reabsorbing and reforming bone. The cost to society with our aging population and individuals who become disabled by hip fractures could triple by the year 2040.The proposed project studies a novel factor that controls bone mass. Its potential is for therapeutic treatment.
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会议论文
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批准号:nhmrc : 634511
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项目类别:Project Grants
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资助金额:$37.72万
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财政年份:2010
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负责人:Prof Jiake Xu
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依托单位:
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批准号:nhmrc : 572670
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项目类别:NHMRC Project Grants
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资助金额:$44.78万
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财政年份:2009
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负责人:Prof Jiake Xu
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依托单位:
Regulation of osteoclast differentiation and function by the PKC pathway.
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批准号:nhmrc : 513832
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项目类别:NHMRC Project Grants
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资助金额:$28.28万
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财政年份:2008
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负责人:Prof Jiake Xu
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依托单位:
V-ATPases subunit d2 is critical for acdification and bone resorption.
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批准号:nhmrc : 404065
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项目类别:NHMRC Project Grants
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资助金额:$35.42万
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财政年份:2006
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负责人:Prof Jiake Xu
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依托单位:
Structural and functional analyses of rat receptor activator of NF-kb ligand
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批准号:nhmrc : 212027
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项目类别:NHMRC Project Grants
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资助金额:$15.09万
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财政年份:2002
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负责人:Prof Jiake Xu
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依托单位:
Caltrin as a calcium transport inhibitor during osteoclastic bone resorption
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批准号:nhmrc : 139137
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项目类别:NHMRC Project Grants
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资助金额:$13.1万
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财政年份:2001
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负责人:Prof Jiake Xu
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依托单位:
海外基金