The role of the systemic milieu in preventing motor unit remodelling and loss during ageing

运动单元的重塑和丧失导致了我们老龄化人口中肌肉质量、力量和生活质量的下降。最近的数据显示，将老年小鼠暴露于年轻小鼠血液循环中的“血源性因素”中，可以逆转与年龄相关的运动单元结构和功能缺陷。更好地了解控制这些抗衰老作用的因素对于发现新的化合物来逆转衰老过程和提高生活质量至关重要。

Motor unit remodeling and loss contributes to the decline in muscle mass, strength and quality of life in our aging population. Recent data shows that exposing aged mice to 'blood-borne factors' from the circulation of a young mouse can reverse the age-associated deficits in motor unit structure and function. A better understanding of the factors controlling these anti-aging effects will be vital for finding new compounds to reverse the aging process and improve quality of life.