Screening for Recently Defined Genetic Lesions in Poor Risk Adult and Childhood ALL, and Developing Treatment Approaches to Target Causative Pathways.

大多数成人和20%的儿童ALL复发并死于疾病。最近在大量病例中发现了导致新蛋白质形成的染色体变化。重要的是，靶向这些蛋白质的药物在临床实践中用于其他疾病。我们将开发新的检测方法，以在诊断时快速识别这些患者，并在临床试验中评估将这些药物添加到一线治疗的疗效。使用这种方法，这些患者的结局可能会显著改善

Most adults and 20% of children with ALL relapse and die of their disease. Chromosomal changes resulting in the formation of new proteins have been recently identified in a significant number of cases. Importantly, drugs targeting these proteins are in clinical practice for other diseases. We will develop new tests to rapidly identify these patients at diagnosis, and assess the efficacy of adding these drugs to first line treatment in a clinical trial. The outcome for these patients will likely improve significantly using this approach