Signal integration of chimeric antigen receptors and the inhibitory Programmed cell death protein 1 receptor

T细胞通过整合激活和抑制表面受体的信息来识别和杀死感染或癌细胞，并耐受健康组织。为靶向癌症而设计的激活受体在治疗方面显示出巨大的前景，但它们对癌症所利用的内源性抑制受体的敏感性尚不清楚。我们将使用强大的生化和显微技术来探索这个问题。这一结果将为设计更有效的抗癌疗法提供参考。

T cells recognise and kill infected or cancerous cells and tolerate healthy tissue by integrating information from activating and inhibitory surface receptors. Activating receptors engineered to target cancer show great promise as therapies but their sensitivity to endogenous inhibitory receptors, which cancers exploit, is unknown. We will use powerful biochemical and microscopy techniques to probe this question. The results will inform the design of more effective anti-cancer therapeutics.