Statistical issues in the analysis of host-viral genetic associations

艾滋病毒或乙肝或丙型肝炎等病毒可能会逃脱人类宿主免疫系统的检测，从而通过策略性突变进行控制。该项目旨在制定统计方法，以便利确定这些战略突变的位置，并评估不同的人类-宿主遗传特征的相对影响。这些结果的应用将有助于定制疫苗的设计和耐药性研究。

Viruses such as HIV or Hepatitis B or C may escape detection, and hence control, by the human host immune system through strategic mutations. This project aims to develop statistical methodologies which will facilitate determination of the locations of these strategic mutations and assess the relative impact of different human-host genetic characteristics. Application of the results should benefit the design of tailored vaccines and studies of drug resistance.