STICs and STONes: A Randomised, Phase II, Double-Blind, Placebo-Controlled Trial of Aspirin in Chemoprevention of Ovarian Cancer in Women with BRCA1 and BRCA2 Mutations

BRCA1或BRCA2基因异常的女性患卵巢癌和输卵管癌的风险更高，为了预防癌症，她们经常被切除卵巢和输卵管(O&FT)。手术时经常会看到微小的癌症。一些研究表明，阿司匹林可能会降低O&FT的癌症风险。这项研究将让女性在接受预防性妇产科手术前，每天服用阿司匹林或安慰剂6-24个月。这将使我们更好地了解O&FT癌症是如何开始的，以及阿司匹林可能产生的影响。

Women with a BRCA1 or BRCA2 gene abnormality are at increased risk of ovary and fallopian tube (O&FT) cancers and often have their O&FTs removed to prevent cancer. Microscopic cancers are often seen at the time of surgery. Some studies suggest that aspirin might reduce O&FT cancer risk. This study will assign women to daily aspirin or placebo for 6-24 months before their preventive O&FT surgery. It will provide a better understanding of how O&FT cancers start and the influence aspirin may have.