Structural biology of malaria parasite invasion and antibodies-mediated inhibition

疟疾导致大量死亡，但尚不存在有效的疫苗。Rh5-CyRPA-Ripr复合体是疟疾寄生虫入侵红细胞所必需的，是主要的候选疫苗。我们的目标是可视化在寄生虫入侵红细胞过程中Rh5-CyRPA-Ripr复合体的原子细节，以及抗体如何中和这一关键蛋白质复合体。这些信息将促进对疟疾寄生虫入侵的了解，这将有助于设计有效的疟疾疫苗。

Malaria results in significant mortality but an effective vaccine does not yet exist. The Rh5-CyRPA-Ripr complex is essential for malaria parasite to invade erythrocytes and is the leading vaccine candidate. We aim to visualise the atomic details of the Rh5-CyRPA-Ripr complex during parasite invasion of erythrocytes and how antibodies neutralise this key protein complex. This information will advance knowledge on malaria parasite invasion, which will help to design an effective malaria vaccine.